Permission to Use the CPSI and PSQ

For permission to use the CPSI or PSQ, please submit the License Request. If you require immediate assistance, please contact us.

Chronic Pain Sleep Inventory (CPSI)

Pain and Sleep Questionnaire (PSQ-3)

The Chronic Pain Sleep Inventory© (CPSI©), sometimes referred to as the Pain and Sleep Questionnaire© (PSQ-3©) is a 5-item proprietary self-administered sleep questionnaire protected by copyright. It is a widely used tool to evaluate the role of pain in sleep interference, both in analgesic clinical trials and clinical practice. CPSI Version 2.0 (CPSI-3©), sometimes referred to as PSQ-3© uses 3 of the 5-items where all items attribute sleep problems to pain to form a unidimensional construct. The preferred name of this instrument is Chronic Pain Sleep Inventory© (CPSI©) or CPSI Version 2.0 (CPSI-3©).

Why Assess Sleep in Analgesic Clinical Trials?

Patients with chronic pain, including cancer pain, musculoskeletal pain (e.g., osteoarthritis, low back pain), fibromyalgia and neuropathic pain (e.g., painful diabetic neuropathy, postherpetic neuralgia and painful HIV associated neuropathy) frequently present with a wide variety of comorbid pathologies that may or may not be causally related to their chronic pain. Self-reports and polysomnographic findings have long suggested that sleep disturbances are common in patients with chronic pain, with higher pain intensity scores correlating with greater sleep impairment. However, until relatively recently, efficacy outcomes in clinical trials focused only on relief from pain, joint stiffness and improvements in physical function. Furthermore, there was little information on the epidemiology of sleep disturbance in chronic pain and on the effects of analgesic treatment on sleep impairment.

General Description of the CPSI and PSQ-3

The CPSI and CPSI Version 2.0 (CPSI-3), sometimes referred to as the Pain and Sleep Questionnaire (PSQ-3)  are proprietary sleep questionnaires protected by copyright. They were developed in the English language (U.S.) and have undergone translation in approximately two dozen languages. They have been used to successfully document the effects of therapeutic interventions on various sleep characteristics in randomized clinical trials by numerous pharmaceutical companies and included in New Drug Applications (NDAs) as VAS and Lickert scales, in paper and electronic form.

Available Languages

The Chronic Pain Sleep Inventory© (CPSI©) and the CPSI Version 2.0 (CPSI-3©), sometimes referred to as PSQ-3© was developed in English for the USA and is available in 23 languages. The listed translations may not have undergone a full linguistic validation process and may require further work to be suitable for use in a study. This list is subject to constant changes, therefore please check the status of translations or contact us using this link to the Contact Form.

Country Language Country Language Country Language
Australia English Germany German Russia Russian
Austria German Israel Hebrew Serbia Serbian
Belgium Dutch Israel Arabic Slovak Slovakian
Belgium French Israel Russian Slovenia Slovenian
Bulgaria Bulgarian Italy Italian Spain Spanish
Canada English Latvia Latvian Taiwan Mandarin (traditional)
Canada French Latvia Russian UK English
Croatia Croatian Moldova Romanian Ukraine Ukrainian
Czechia Czech Norway Norwegian Ukraine Russian
Denmark Danish Poland Polish USA English
France French Romania Romanian USA Spanish

Conditions of Use


The Chronic Pain Sleep Inventory© (CPSI©), CPSI Version 2.0 (CPSI-3©) and PSQ-3© are proprietary sleep questionnaires protected by copyright. Licensing processes and costs are determined based on information specific to each research project.

Students, Physicians, Clinical Practice, Not-Funded Academic Users

No charge, subject to execution of a license and copyright agreement. To obtain permission, a request may be submitted using the License Request. We will get back to you with the needed information and license agreement in a timely manner. If you require immediate assistance, please use the Contact Form.

Funded Academic Users, Commercial Users & IT Companies

Costs are determined on the basis of information specific to each research project. Use is subject to a license and copyright agreement. To obtain permission, a request may be submitted using the License Request. We will get back to you with the needed information and license agreement in a timely manner. If you require immediate assistance, please use the Contact Form.

Bibliography

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Lazzari M, Sabato AF, Caldarulo C, Casali M, Gafforio P, Marcassa C, Leonardis F. Effectiveness and tolerability of low-dose oral oxycodone/naloxone added to anticonvulsant therapy for noncancer neuropathic pain: an observational analysis. Curr Med Res Opin. 2014 Apr;30(4):555-64. doi: 10.1185/03007995.2013.866545.

Florete OG, Xiang J, Vorsanger GJ. Effects of extended-release tramadol on pain-related sleep parameters in patients with osteoarthritis. Expert Opin Pharmacother. 2008 Aug;9(11):1817-27. doi: 10.1517/14656566.9.11.1817.

Kosinski M, Janagap CC, Gajria K, Schein J. Psychometric testing and validation of the Chronic Pain Sleep Inventory. Clin Ther. 2007;29 Suppl:2562-77. doi: 10.1016/j.clinthera.2007.12.001.

Kosinski M, Janagap C, Gajria K, Schein J, Freedman J. Pain relief and pain-related sleep disturbance with extended-release tramadol in patients with osteoarthritis. Curr Med Res Opin. 2007 Jul;23(7):1615-26. doi: 10.1185/030079907×199493.

Kivitz A, Ma C, Ahdieh H, Galer BS. A 2-week, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, phase III trial comparing the efficacy of oxymorphone extended release and placebo in adults with pain associated with osteoarthritis of the hip or knee. Clin Ther. 2006 Mar;28(3):352-64. doi: 10.1016/j.clinthera.2006.03.008.

Babul N, Noveck R, Chipman H, Roth SH, Gana T, Albert K. Efficacy and safety of extended-release, once-daily tramadol in chronic pain: a randomized 12-week clinical trial in osteoarthritis of the knee. J Pain Symptom Manage. 2004 Jul;28(1):59-71. doi: 10.1016/j.jpainsymman.2003.11.006.

Babul N, Noveck R. Chronic Pain Sleep Inventory for evaluation of treatment responses to opioid analgesics: randomized, placebo- controlled clinical trials in OA. Proceedings of the CHANGE “Copyright© 1997 – 2019 …… affiliates. All Rights Reserved. Chronic Pain ……. or its affiliates.” TO Copyright© 1997-2021, Cinergen, LLC or its affiliates. All Rights Reserved. Chronic Pain Sleep Inventory is a registered trademark and copyright property of Cinergen, LLC or its affiliates.”

American Pain Society 22nd Annual Scientific Meeting, March 20-23, 2003, Chicago, Illinois.